pentobarbital will lower the level or influence of pitolisant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Intently. Pitolisant exposure is lowered by 50% if coadministered with robust CYP3A4 inducers.Contraindicated (one)pentobarbital will minimize the level or impact of lumacaftor/ivacaftor by impacting hepatic/i